A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3

Chem Commun (Camb). 2015 Oct 4;51(77):14520-3. doi: 10.1039/c5cc04962h. Epub 2015 Aug 18.

Abstract

A novel dual-FRET-based fluorescence probe was designed and synthesized for the sequential detection of MMP-2 and caspase-3. This probe can successfully monitor Dox- and UV-induced cell apoptosis signals in real time and in situ, which demonstrated its great potential for apoptosis-related drug screening and dynamic apoptosis imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Caspase 3 / analysis*
  • Cell Line, Tumor
  • Chlorocebus aethiops
  • Fluorescence Resonance Energy Transfer
  • Fluorescent Dyes / chemistry*
  • Humans
  • Matrix Metalloproteinase 2 / analysis*

Substances

  • Fluorescent Dyes
  • Caspase 3
  • Matrix Metalloproteinase 2