Non-Covalent Derivatives: Cocrystals and Eutectics

Molecules. 2015 Aug 14;20(8):14833-48. doi: 10.3390/molecules200814833.


Non-covalent derivatives (NCDs) are formed by incorporating one (or more) coformer molecule(s) into the matrix of a parent molecule via non-covalent forces. These forces can include ionic forces, Van der Waals forces, hydrogen bonding, lipophilic-lipophilic interactions and pi-pi interactions. NCDs, in both cocrystal and eutectic forms, possess properties that are unique to their supramolecular matrix. These properties include critical product performance factors such as solubility, stability and bioavailability. NCDs have been used to tailor materials for a variety of applications and have the potential to be used in an even broader range of materials and processes. NCDs can be prepared using little or no solvent and none of the reagents typical to synthetic modifications. Thus, NCDs represent a powerfully versatile, environmentally-friendly and cost-effective opportunity.

Keywords: cocrystals; eutectics; green chemistry; non-covalent derivative.

Publication types

  • Review

MeSH terms

  • Agrochemicals / chemistry
  • Cosmetics / chemistry
  • Crystallization
  • Food Additives / chemistry
  • Temperature*


  • Agrochemicals
  • Cosmetics
  • Food Additives