Ebola Virus Disease: A Review of Its Past and Present

Anesth Analg. 2015 Sep;121(3):798-809. doi: 10.1213/ANE.0000000000000866.


Ebola virus, the virus responsible for Ebola virus disease, has spawned several epidemics during the past 38 years. In 2014, an Ebola epidemic spread from Africa to other continents, becoming a pandemic. The virus's relatively unique structure, its infectivity and lethality, the difficulty in stopping its spread, and the lack of an effective treatment captured the world's attention. This article provides a brief review of the known history of Ebola virus disease, its etiology, epidemiology, and pathophysiology and a review of the limited information on managing patients with Ebola virus disease.

Publication types

  • Review

MeSH terms

  • Africa / epidemiology
  • Disease Outbreaks / prevention & control
  • Ebolavirus / isolation & purification*
  • Epidemics / prevention & control
  • Hemorrhagic Fever, Ebola / diagnosis*
  • Hemorrhagic Fever, Ebola / epidemiology*
  • Hemorrhagic Fever, Ebola / therapy
  • Humans