POPsicle for Fever! Cooling Down the Inflammasome

Immunity. 2015 Aug 18;43(2):213-5. doi: 10.1016/j.immuni.2015.08.004.

Abstract

Inhibition of the inflammasome might be beneficial for numerous inflammatory pathologies. In this issue of Immunity, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits inflammasome activation, identifying it as a pan-inflammasome inhibitor.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cryopyrin-Associated Periodic Syndromes / immunology*
  • Dendritic Cells / immunology*
  • Female
  • Humans
  • Inflammasomes / metabolism*
  • Macrophages, Peritoneal / immunology*
  • Monocytes / immunology*
  • Peritonitis / immunology*
  • Ribonucleoproteins / metabolism*

Substances

  • Inflammasomes
  • Ribonucleoproteins