Ocular pseudoexfoliation syndrome and life span

Jon Klokk Slettedal; Leiv Sandvik; Amund Ringvold

doi:10.1016/j.ebiom.2015.05.024

Ocular pseudoexfoliation syndrome and life span

EBioMedicine. 2015 May 30;2(7):765-9. doi: 10.1016/j.ebiom.2015.05.024. eCollection 2015 Jul.

Authors

Jon Klokk Slettedal¹, Leiv Sandvik², Amund Ringvold³

Affiliations

¹ Institute of Clinical Medicine, University of Oslo, Norway ; Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.
² Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Norway.
³ Institute of Clinical Medicine, University of Oslo, Norway.

Abstract

Background: To compare life span of persons with and without ocular pseudoexfoliation syndrome (PES).

Methods: The study is based on an epidemiological survey conducted in Sør-Trøndelag county, Norway, in 1985-86. All inhabitants over 64 years of age (2109 individuals) were invited. Mortality information was obtained from The Norwegian Institute of Public Health in 2014, by which time 99% of the participants were deceased.

Results: When adjusting for age and gender, life span was not statistically different in persons with and without PES. Following the diagnosis of PES, patients' survival was up to, and beyond, 30 years.

Conclusions: Our observations suggest that, despite all the systemic aberrations reported in persons with ocular PES, none or only marginal functional changes are caused in extraocular organs and tissues. The present study supports the notion that systemic PES is not a life-threatening condition.

Keywords: Cardiovascular disease; Eye; Life span; Mortality; Ophthalmology; Pseudoexfoliation syndrome; Survey.

MeSH terms

Aged
Aged, 80 and over
Exfoliation Syndrome / epidemiology
Exfoliation Syndrome / mortality*
Humans
Kaplan-Meier Estimate
Longevity*
Norway / epidemiology
Prevalence