Examination of angiopoietin-like protein 4, neuropeptide Y, omentin-1 levels of obese and non-obese patients with polycystic ovary syndrome

Gynecol Endocrinol. 2015;31(11):903-6. doi: 10.3109/09513590.2015.1068285. Epub 2015 Aug 18.

Abstract

The pathogenesis of polycystic ovary syndrome (PCOS) and obesity is not clarified yet. But some parameters such as neuropeptide Y (NPY), angiopoietin-like protein (Angptl-4), omentin-1 are thought to be involved in this pathogenesis. In this study, we aimed to show possible effects of NPY, Angptl-4, omentin-1 throughout clinical parameters and hormones. Patients were divided into three groups. Group I; healthy volunteers, Group II; non-obese women with PCOS and group III; obese women with PCOS. Serum NPY, Angptl-4, free testosterone, total testosterone, luteinize hormone, sex hormone binding globulin, estradiol, dehydroepiandrosterone sulfate, androstenedione, triglycerides and low density lipoprotein cholesterol levels and HOMA-IR, Ferriman-Galwey scores were significantly higher in group II when compared with group I and similarly in group III when compared with group II (p < 0.005). While comparing all PCOS patients (obese + non-obese) with healthy volunteers, omentin-1 and high density lipoprotein cholesterol levels were significantly low in PCOS group (p < 0.005). As a result of this study, both in the obese and non-obese PCOS patients, there was a significant increase in levels of NPY and Angptl-4 and a significant decline in omentin-1 when compared to healthy subjects. In conclusion, insulin resistance in PCOS patients may be related to the differences of NPY, Angptl-4 and omentin-1 levels and the effects of these differences on metabolic pathways.

Keywords: Angptl-4; NPY; obesity; omentin-1; polycystic ovary syndrome.

MeSH terms

  • Adult
  • Androstenedione / blood
  • Angiopoietin-Like Protein 4
  • Angiopoietins / blood*
  • Case-Control Studies
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cytokines / blood*
  • Dehydroepiandrosterone Sulfate / blood
  • Estradiol / blood
  • Female
  • GPI-Linked Proteins / blood
  • Humans
  • Insulin Resistance
  • Lectins / blood*
  • Luteinizing Hormone / blood
  • Neuropeptide Y / blood*
  • Obesity / blood*
  • Obesity / complications
  • Polycystic Ovary Syndrome / blood*
  • Polycystic Ovary Syndrome / complications
  • Sex Hormone-Binding Globulin / metabolism
  • Testosterone / blood
  • Triglycerides / blood

Substances

  • ANGPTL4 protein, human
  • Angiopoietin-Like Protein 4
  • Angiopoietins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins
  • Neuropeptide Y
  • Sex Hormone-Binding Globulin
  • Triglycerides
  • Testosterone
  • Androstenedione
  • Estradiol
  • Dehydroepiandrosterone Sulfate
  • Luteinizing Hormone