M-Protein Analysis of Streptococcus Pyogenes Isolates Associated With Acute Rheumatic Fever in New Zealand

J Clin Microbiol. 2015 Nov;53(11):3618-20. doi: 10.1128/JCM.02129-15. Epub 2015 Aug 19.

Abstract

We applied an emm cluster typing system to group A Streptococcus strains in New Zealand, including those associated with acute rheumatic fever (ARF). We observed few so-called rheumatogenic emm types but found a high proportion of emm types previously associated with pyoderma, further suggesting a role for skin infection in ARF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / genetics*
  • Bacterial Outer Membrane Proteins / genetics*
  • Carrier Proteins / genetics*
  • Humans
  • Molecular Epidemiology / methods
  • Molecular Typing
  • New Zealand / epidemiology
  • Retrospective Studies
  • Rheumatic Fever / epidemiology*
  • Rheumatic Fever / microbiology
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / classification*
  • Streptococcus pyogenes / genetics
  • Streptococcus pyogenes / isolation & purification*
  • Streptococcus pyogenes / pathogenicity

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins
  • streptococcal M protein