Review article: BK virus in systemic lupus erythematosus

Pediatr Rheumatol Online J. 2015 Aug 21:13:34. doi: 10.1186/s12969-015-0033-9.


BK virus (BKV) is a human polyomavirus with a seroprevalence of 60-80 % in the general population. In renal transplant patients, it is known to cause renal failure, ureteric stenosis and hemorrhagic cystitis. In bone marrow transplant patients, it is evident that BKV can also cause hemorrhagic cystitis along with BK virus nephropathy (BKVN) in the native kidneys, with subsequent renal failure. However, little is known about BVKN in non-transplanted immune-compromised patients, such as systemic lupus erythematosus (SLE) who may have underlying nephritis and have a compromised immune system due to therapy and/or systemic illness. Thus, this article will focus on the clinical aspects of BKV and its association in patients with SLE.

Publication types

  • Review

MeSH terms

  • BK Virus*
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / virology*
  • Polyomavirus Infections / complications*
  • Polyomavirus Infections / epidemiology
  • Tumor Virus Infections / complications*
  • Tumor Virus Infections / epidemiology