Clinical Research Informatics: Recent Advances and Future Directions

Yearb Med Inform. 2015 Aug 13;10(1):174-7. doi: 10.15265/IY-2015-010.


Objectives: To summarize significant developments in Clinical Research Informatics (CRI) over the past two years and discuss future directions.

Methods: Survey of advances, open problems and opportunities in this field based on exploration of current literature.

Results: Recent advances are structured according to three use cases of clinical research: Protocol feasibility, patient identification/ recruitment and clinical trial execution.

Discussion: CRI is an evolving, dynamic field of research. Global collaboration, open metadata, content standards with semantics and computable eligibility criteria are key success factors for future developments in CRI.

Keywords: Clinical research informatics; clinical trial execution; open metadata; patient recruitment; protocol feasibility; semantic annotation.

MeSH terms

  • Biomedical Research* / organization & administration
  • Clinical Trials as Topic / organization & administration
  • Documentation
  • Electronic Health Records
  • Information Storage and Retrieval
  • Medical Informatics*
  • Systems Integration