Neurodegeneration: A Leg Up on TDP-43

Matthew D Figley; Aaron D Gitler

doi:10.1016/j.cub.2015.06.064

Neurodegeneration: A Leg Up on TDP-43

Curr Biol. 2015 Aug 17;25(16):R728-31. doi: 10.1016/j.cub.2015.06.064.

Authors

Matthew D Figley¹, Aaron D Gitler²

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: figley@stanford.edu.
² Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.

PMID: 26294190
DOI: 10.1016/j.cub.2015.06.064

Abstract

TDP-43 is a key disease protein for amyotrophic lateral sclerosis but how it drives motor neuron degeneration remains unresolved. A new study has modeled TDP-43 age-dependent axonal death in the Drosophila leg and used a powerful forward genetic screen to identify three novel suppressor genes.

Publication types

Comment

MeSH terms

Aging*
Amyotrophic Lateral Sclerosis / genetics*
Animals
DNA-Binding Proteins / genetics*
Drosophila Proteins / genetics*
Drosophila melanogaster / physiology*
Humans
Motor Neurons / physiology*
Nerve Degeneration / genetics*

Substances

DNA-Binding Proteins
Drosophila Proteins