Over 50 Years of Fibrinogen Concentrate

Clin Appl Thromb Hemost. 2016 Mar;22(2):109-14. doi: 10.1177/1076029615601494. Epub 2015 Aug 19.


March 2013 represented the 50th anniversary of the first license granted for a fibrinogen concentrate. In this review, we look at the history of bleeding management that led to the development of fibrinogen concentrate, discuss its current use, and consider future developments for this product.

Keywords: bleeding; blood coagulation factors; hemostasis.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anniversaries and Special Events
  • Fibrinogen / history
  • Fibrinogen / therapeutic use*
  • Hemorrhage / drug therapy*
  • Hemorrhage / history
  • History, 20th Century
  • History, 21st Century
  • Humans


  • Fibrinogen