Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation

Small. 2015 Oct 28;11(40):5360-8. doi: 10.1002/smll.201501573. Epub 2015 Aug 21.


By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.

Keywords: DNA-brush block copolymers; cellular uptake; gene regulation; micelles; spherical nucleic acids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemistry
  • Micelles*
  • Nucleic Acids / chemistry*
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*


  • Micelles
  • Nucleic Acids
  • Polymers
  • Polyethylene Glycols
  • DNA