Imaging in pleural mesothelioma: A review of the 12th International Conference of the International Mesothelioma Interest Group

Lung Cancer. 2015 Nov;90(2):148-54. doi: 10.1016/j.lungcan.2015.07.011. Epub 2015 Jul 29.


Imaging of malignant pleural mesothelioma is essential to patient management, prognostication, and response assessment. From animal models to clinical trials, the gamut of research activities and clinical standards relies on imaging to provide information on lesion morphology and the growing number of physiologic characteristics amenable to capture through imaging techniques. The complex morphology, growth pattern, and biological mechanisms of mesothelioma, however, present challenges for image acquisition and interpretation. Nevertheless, novel approaches to image acquisition and subsequent image analysis have expanded the opportunities for (as well as the need for) imaging in this disease. This paper summarizes the imaging-based research presented orally at the 2014 International Conference of the International Mesothelioma Interest Group (iMig) in Cape Town, South Africa, October 2014. Presented topics include the imaging of hypoxia in a murine model through positron emission tomography (PET), the use of diffusion-weighted magnetic resonance imaging (MRI) to assess the histologic composition of biphasic mesothelioma and to assess early response to chemotherapy, the correlation of CT-based tumor volume with the volume of the post-surgical tumor specimen, the development of volumetric tumor response criteria, and pre-treatment tumor volume growth considerations for tumor response assessment.

Keywords: Apparent diffusion coefficient; Diffusion-weighted MRI; F-MISO; Mesothelioma; PET/CT; Pre-clinical imaging; Tumor histology; Tumor hypoxia; Tumor response assessment; Tumor response criteria; Tumor volume; Tumor volume growth rate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diffusion Magnetic Resonance Imaging / methods
  • Humans
  • Lung Neoplasms / pathology*
  • Mesothelioma / pathology*
  • Mesothelioma, Malignant
  • Pleural Neoplasms / pathology*
  • Positron-Emission Tomography / methods
  • Tomography, X-Ray Computed / methods
  • Tumor Burden / physiology