Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

J Neuroimmunol. 2015 Sep 15;286:33-41. doi: 10.1016/j.jneuroim.2015.07.003. Epub 2015 Jul 11.

Abstract

Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.

Keywords: Asthma; Autism; Food allergies; IL-17.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Asthma / epidemiology
  • Asthma / pathology*
  • Case-Control Studies
  • Child Development Disorders, Pervasive / epidemiology
  • Child Development Disorders, Pervasive / pathology*
  • Child, Preschool
  • Cytokines / metabolism
  • Female
  • Humans
  • Interleukin-7 / metabolism*
  • Male
  • Mitogens / pharmacology
  • Phytohemagglutinins / pharmacology
  • Statistics, Nonparametric
  • Th17 Cells / drug effects
  • Th17 Cells / metabolism*
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism*

Substances

  • Cytokines
  • IL7 protein, human
  • Interleukin-7
  • Mitogens
  • Phytohemagglutinins