Biodistribution of boron after intravenous 4-dihydroxyborylphenylalanine-fructose (BPA-F) infusion in meningioma and schwannoma patients: A feasibility study for boron neutron capture therapy

Appl Radiat Isot. 2015 Dec:106:207-12. doi: 10.1016/j.apradiso.2015.08.006. Epub 2015 Aug 10.

Abstract

We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment.

Keywords: BNCT; Meningioma; NF2; Schwannoma.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Boron / pharmacokinetics*
  • Boron Compounds / administration & dosage*
  • Boron Neutron Capture Therapy*
  • Brain Neoplasms / radiotherapy*
  • Feasibility Studies
  • Female
  • Fructose / administration & dosage*
  • Humans
  • Infusions, Intravenous
  • Male
  • Meningioma / radiotherapy*
  • Middle Aged
  • Neurilemmoma / radiotherapy*
  • Phenylalanine / administration & dosage
  • Phenylalanine / analogs & derivatives*
  • Tissue Distribution
  • Young Adult

Substances

  • 4-dihydroxyborylphenylalanine
  • Boron Compounds
  • Fructose
  • Phenylalanine
  • Boron