Abstract
Background:
Neurolymphomatosis (NL) is an extremely rare disease and tracheal asphyxia due to NL has not been previously reported.
Case presentation:
A 54-year-old Chinese woman with a history of diffuse large B-cell lymphoma in her first complete remission developed peripheral neuropathy and tracheal asphyxia. Neurolymphomatosis involving the right brachial plexus and the right vagus nerve was demonstrated by PET/CT, but not by MRI. She underwent urgent tracheotomy and impact chemotherapy using rituximab combined with high dose methotrexate and involved field radiotherapy. She achieved a second complete remission.
Conclusion:
PET/CT plays valuable role in differentiating NL from other neuropathies in patients with lymphoma. Complete remission can be achieved in NL due to large B-cell lymphoma.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / therapeutic use
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Asphyxia / diagnosis
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Asphyxia / etiology*
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Asphyxia / surgery
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Brachial Plexus / diagnostic imaging
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Female
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Humans
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / therapy
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Methotrexate / therapeutic use
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Middle Aged
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Multimodal Imaging
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Peripheral Nervous System Diseases / etiology*
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Peripheral Nervous System Neoplasms / complications*
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Peripheral Nervous System Neoplasms / diagnosis
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Peripheral Nervous System Neoplasms / secondary
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Peripheral Nervous System Neoplasms / therapy
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Positron-Emission Tomography
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Radiotherapy
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Rituximab / therapeutic use
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Tomography, X-Ray Computed
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Tracheal Diseases / diagnosis
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Tracheal Diseases / etiology*
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Tracheal Diseases / surgery
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Tracheotomy
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Vagus Nerve / diagnostic imaging
Substances
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Antineoplastic Agents
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Rituximab
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Methotrexate