Anti-obesity activity of the water extract of Lactobacillus paracasei subsp. paracasei NTU 101 fermented soy milk products

Food Funct. 2015 Nov;6(11):3522-30. doi: 10.1039/c5fo00531k. Epub 2015 Aug 24.


The anti-obesity activity of the water extract of soy milk fermented with Lactobacillus paracasei subsp. paracasei NTU 101 (W101) was investigated. A high-fat diet (HFD) was used to induce obesity in rats, and the effects of daily W101 feeding (8 weeks) were observed. The rats fed the HFD and supplemented with low-dose W101 (LW101, 15 mg per kg body weight per day) or high-dose W101 (HW101, 150 mg per kg body weight per day) had significantly reduced final body weight in comparison with that of the HFD group. W101 decreased the formation of lipid plaques in the aorta, reduced the adipocyte cross-sectional area and diameter, and reduced the levels of CCAAT/enhancer-binding protein β (C/EBPβ), peroxisome proliferator associated receptor γ (PPARγ), and C/EBPα. Regarding lipogenesis regulation in adipocytes, W101 suppressed heparin-releasable lipoprotein lipase (HR-LPL) in adipose tissues and inhibited lipid absorption, thereby reducing lipogenesis. Lactobacillus paracasei subsp. paracasei NTU 101-fermented soy milk may be used to develop health foods that prevent obesity.

MeSH terms

  • Adipocytes / drug effects
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Body Weight / drug effects
  • CCAAT-Enhancer-Binding Protein-alpha / metabolism
  • CCAAT-Enhancer-Binding Protein-beta / metabolism
  • Cultured Milk Products / chemistry*
  • Cultured Milk Products / microbiology
  • Diet, High-Fat / adverse effects
  • Dietary Fats / adverse effects
  • Lactobacillus / metabolism
  • Lipogenesis / drug effects
  • Lipoprotein Lipase / metabolism
  • Male
  • Obesity / drug therapy*
  • Obesity / etiology
  • PPAR gamma / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Soy Milk / chemistry*
  • Water*


  • Anti-Obesity Agents
  • CCAAT-Enhancer-Binding Protein-alpha
  • CCAAT-Enhancer-Binding Protein-beta
  • Dietary Fats
  • PPAR gamma
  • Water
  • Lipoprotein Lipase