Maternal Obesity and Rectovaginal Group B Streptococcus Colonization at Term

Infect Dis Obstet Gynecol. 2015;2015:586767. doi: 10.1155/2015/586767. Epub 2015 Aug 2.

Abstract

Objective: To test the hypothesis that maternal obesity is an independent risk factor for rectovaginal group B streptococcus (GBS) colonization at term.

Study design: Retrospective cohort study of consecutive women with singleton term pregnancies admitted in labor at Barnes-Jewish Hospital (2004-2008). Maternal BMI≥30 Kg/m2 (obese) or <30 Kg/m2 (nonobese) defined the two comparison groups. The outcome of interest was GBS colonization from a positive culture. Baseline characteristics were compared using Student's t-test and Chi-squared or Fisher's exact test. The association between obesity and GBS colonization was assessed using univariable and multivariable analyses.

Results: Of the 10,564 women eligible, 7,711 met inclusion criteria. The prevalence of GBS colonization in the entire cohort was relatively high (25.8%). Obese gravidas were significantly more likely to be colonized by GBS when compared with nonobese gravidas (28.4% versus 22.2%, P<0.001). Obese gravidas were still 35% more likely than nonobese women to test positive for GBS after adjusting for race, parity, smoking, and diabetes (adjusted OR 1.35 [95% CI 1.21-1.50]).

Conclusion: Maternal obesity is a significant risk factor for GBS colonization at term. Further research is needed to evaluate the impact of this finding on risk-based management strategies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Body Mass Index
  • Female
  • Humans
  • Obesity / complications*
  • Obesity / epidemiology
  • Obesity / physiopathology
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / etiology
  • Pregnancy Complications / microbiology*
  • Retrospective Studies
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / etiology
  • Streptococcal Infections / microbiology*
  • Streptococcus agalactiae / genetics
  • Streptococcus agalactiae / isolation & purification*
  • Streptococcus agalactiae / physiology
  • Young Adult