Studies on the panaxytriol of Panax ginseng C. A. Meyer. Isolation, determination and antitumor activity

Chem Pharm Bull (Tokyo). 1989 May;37(5):1279-81. doi: 10.1248/cpb.37.1279.


An antitumor-active substance was obtained from the residue of the ethyl acetate extract of red ginseng, a traditional Chinese medicine, by chromatography on a silica gel column. From the proton and carbon-13 nuclear magnetic resonance spectra, it was identified as heptadeca-1-ene-4,6-diyne-3,9,10-triol (panaxytriol). The panaxytriol contents of red ginseng and white ginseng, determined by gas chromatography after solvent extraction and formation of trimethylsilyl derivatives, were 0.38 and 0.25 mg/g, respectively. Panaxytriol showed a growth-inhibitory activity against several tumor cell lines.

MeSH terms

  • Alkynes
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Chemical Phenomena
  • Chemistry
  • Enediynes
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Panax / analysis*
  • Plants, Medicinal*
  • Tumor Cells, Cultured / drug effects


  • Alkynes
  • Antineoplastic Agents, Phytogenic
  • Enediynes
  • Fatty Alcohols
  • panaxytriol