The Role of Cardiolipin in Cardiovascular Health

Biomed Res Int. 2015:2015:891707. doi: 10.1155/2015/891707. Epub 2015 Aug 2.

Abstract

Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation. BTHS is caused by mutations in the gene encoding tafazzin, the transacylase that carries out the second CL remodeling step. In addition to BTHS, CL is linked to other cardiovascular diseases (CVDs), including cardiomyopathy, atherosclerosis, myocardial ischemia-reperfusion injury, heart failure, and Tangier disease. The link between CL and CVD may possibly be explained by the physiological roles of CL in pathways that are cardioprotective, including mitochondrial bioenergetics, autophagy/mitophagy, and mitogen activated protein kinase (MAPK) pathways. In this review, we focus on the role of CL in the pathogenesis of CVD as well as the molecular mechanisms that may link CL functions to cardiovascular health.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Barth Syndrome / genetics
  • Barth Syndrome / pathology
  • Cardiolipins / genetics*
  • Cardiolipins / metabolism
  • Cardiomyopathies / genetics
  • Cardiomyopathies / pathology
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular System / metabolism
  • Cardiovascular System / pathology
  • Humans
  • Mitochondria / genetics*
  • Mitochondria / metabolism
  • Mitochondria / pathology
  • Mitochondrial Membranes / metabolism*
  • Mitochondrial Membranes / pathology
  • Mitogen-Activated Protein Kinase Kinases / genetics
  • Signal Transduction

Substances

  • Cardiolipins
  • Mitogen-Activated Protein Kinase Kinases