Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct 22;126(17):2059-61.
doi: 10.1182/blood-2015-03-632844. Epub 2015 Aug 24.

No Evidence of Transmission of Chronic Lymphocytic Leukemia Through Blood Transfusion

Affiliations

No Evidence of Transmission of Chronic Lymphocytic Leukemia Through Blood Transfusion

Henrik Hjalgrim et al. Blood. .

Abstract

Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

Comment in

Similar articles

See all similar articles

Cited by 3 articles

  • Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis.
    Cerhan JR, Kane E, Vajdic CM, Linet MS, Monnereau A, Bernstein L, de Sanjose S, Chiu BC, Spinelli JJ, Maso LD, Zhang Y, Larrabee BR, Cozen W, Smith AG, Clavel J, Serraino D, Zheng T, Holly EA, Weisenberger DD, Slager SL, Bracci PM. Cerhan JR, et al. Cancer Causes Control. 2019 Aug;30(8):889-900. doi: 10.1007/s10552-019-01188-w. Epub 2019 Jun 4. Cancer Causes Control. 2019. PMID: 31165419
  • Chronic lymphocytic leukaemia.
    Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K. Kipps TJ, et al. Nat Rev Dis Primers. 2017 Jan 19;3:16096. doi: 10.1038/nrdp.2016.96. Nat Rev Dis Primers. 2017. PMID: 28102226 Free PMC article. Review.
  • Sixty as the new forty: considerations on older related stem cell donors.
    Anderlini P. Anderlini P. Bone Marrow Transplant. 2017 Jan;52(1):15-19. doi: 10.1038/bmt.2016.201. Epub 2016 Aug 8. Bone Marrow Transplant. 2017. PMID: 27500950 Review.

Publication types

Feedback