Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood

Fitoterapia. 2015 Oct:106:115-21. doi: 10.1016/j.fitote.2015.08.009. Epub 2015 Aug 21.

Abstract

Nine new sesquiterpenes (1-9), together with seventeen known ones (10-26), were isolated from Chinese eaglewood. Their structures were established by extensive spectroscopic analysis, and the absolute configuration of 6 was determined by the modified Mosher's method. Compounds 7, 10, 14, 15, and 21 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values in the range 7.1-53.8 μM.

Keywords: Anti-neuroinflammatory activity; Aquilaria sinensis; Chinese eaglewood; Sesquiterpene; Thymelaeaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Drugs, Chinese Herbal / chemistry*
  • Mice
  • Microglia / drug effects*
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Thymelaeaceae / chemistry*
  • Wood / chemistry

Substances

  • Drugs, Chinese Herbal
  • Sesquiterpenes
  • Nitric Oxide