Resveratrol and anti-atherogenic effects

Int J Food Sci Nutr. 2015;66(6):603-10. doi: 10.3109/09637486.2015.1077796. Epub 2015 Aug 26.


The role of inflammation and oxidative stress in atherosclerosis development has been increasingly well recognized over the past decade. Inflammation has a significant role at all stages of atherosclerosis, including initiation, progression and plaque formation. Resveratrol is a naturally occurring polyphenolic compound found in grape products, berry fruits and red wine. Its ability to behave therapeutically as a component of red wine has attracted wide attention. Accumulating evidence suggests that it is a highly pleiotropic molecule that modulates numerous targets and molecular functions. Epidemiological studies indicate that the Mediterranean diet, rich in resveratrol, is associated with a reduced risk of atherosclerosis. Resveratrol is believed to decrease circulating low-density lipoprotein cholesterol levels, reduce cardiovascular disease risk; it reduces lipid peroxidation, platelet aggregation and oxidative stress. Resveratrol is considered a safe compound, since no significant toxic effects have been demonstrated after administration of a broad range of concentrations, and an effective anti-atherogenic agent.

Keywords: Anti-inflammatory; antioxidant; atherosclerosis; cardiovascular disease; lipids; polyphenol; prevention.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arteriosclerosis / drug therapy*
  • Humans
  • Resveratrol
  • Stilbenes / therapeutic use*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Stilbenes
  • Resveratrol