Group 2 innate lymphoid cells in disease

Int Immunol. 2016 Jan;28(1):13-22. doi: 10.1093/intimm/dxv050. Epub 2015 Aug 25.


Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that ILC2 are present in diverse anatomical locations. The function of ILC2 at these sites is equally varied, and although ILC2 represent a relatively minor population, they are fundamentally important regulators of innate and adaptive immune processes. As such, there is much interest to understand the role of ILC2 in diseases with a type-2 inflammatory component. This review explores the known roles of ILC2 in disease, and the diseases that show associations or other strong evidence for the involvement of ILC2.

Keywords: ILC2; allergies; innate immunity; type-2 inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Humans
  • Hypersensitivity / immunology*
  • Immunity, Innate
  • Immunomodulation
  • Inflammation / immunology*
  • Lymphocytes / immunology*
  • Mucous Membrane / immunology*
  • Th2 Cells / immunology