Genome-wide association study of prostate cancer-specific survival

Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1796-800. doi: 10.1158/1055-9965.EPI-15-0543. Epub 2015 Aug 25.


Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

Results: We observed no significant association between genetic variants and prostate cancer survival.

Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study.

Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genome-Wide Association Study
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / mortality*
  • Survival Analysis