Increased mean platelet volume is related to histologic severity of primary biliary cirrhosis

Eur J Gastroenterol Hepatol. 2015 Dec;27(12):1382-5. doi: 10.1097/MEG.0000000000000463.


Aim: To evaluate the main platelet volume (MPV) as a severity marker in patients with primary biliary cirrhosis (PBC).

Materials and methods: Thirty-nine patients with biopsy-proven and as yet untreated PBC followed between January 2008 and January 2015 were included in this study. Liver biopsies were categorized as early stage (stage 1 and 2 according to Scheuer's histological stage) and late stage (Scheuer's stage 3 and 4). As part of the routine evaluation, all PBC patients had their full blood count and biochemistry profile determined, where MPV, white blood cell count, hemoglobin, platelet count, red cell distribution width (RDW), alanine aminotransferase, aspartate aminotransferase (AST), gamma glutamyl transferase, alkaline phosphatase, and total bilirubin values were evaluated. Both groups were compared in terms of the RDW/platelet ratio, the AST platelet ratio index, and the neutrophil lymphocyte ratio.

Results: Eighteen patients had early-stage disease (46.2%), whereas 21 PBC patients had late-stage disease (53.8%). There were no differences between groups in terms of routine hematological parameters (white blood cell count, platelet count, hemoglobin, RDW) or biochemical parameters (alanine aminotransferase, AST, gamma glutamyl transferase, alkaline phosphatase, total bilirubin, albumin) (P>0.05). Similarly, there were no differences in AST platelet ratio index, RDW/platelet ratio, or neutrophil lymphocyte ratio values between groups (P values 0.08, 0.19, and 0.14, respectively). The MPV and direct bilirubin were significantly higher in the advanced stage group compared with the early-stage group (11.08 vs. 9.73 fl, respectively, P=0.01 and 0.44 vs. 0.28 mg/dl, respectively, P=0.03). The area under the curve, cut-off value, sensitivity, and specificity of MPV and direct bilirubin for detecting advanced stage were 0.721, 10.3, 71%, and 66%, respectively, and 0.698, 0.23, 71%, and 66%, respectively.

Conclusion: MPV can be used as a noninvasive, simple, and effective parameter in patients with PBC to predict histological severity of the disease.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Bilirubin / blood
  • Biomarkers / blood
  • Biopsy
  • Female
  • Humans
  • Liver / pathology
  • Liver Cirrhosis, Biliary / blood*
  • Liver Cirrhosis, Biliary / pathology
  • Male
  • Mean Platelet Volume*
  • Middle Aged
  • ROC Curve
  • Retrospective Studies
  • Sensitivity and Specificity
  • Severity of Illness Index


  • Biomarkers
  • Bilirubin