Characteristics of canine platelet-rich plasma prepared with five commercially available systems

Am J Vet Res. 2015 Sep;76(9):822-7. doi: 10.2460/ajvr.76.9.822.


Objective: To characterize platelet-rich plasma (PRP) products obtained from canine blood by use of a variety of commercially available devices.

Sample: Blood samples from 15 dogs between 18 months and 9 years of age with no concurrent disease, except for osteoarthritis in some dogs.

Procedures: PRP products were produced from blood obtained from each of the 15 dogs by use of each of 5 commercially available PRP-concentrating systems. Complete blood counts were performed on each whole blood sample and PRP product. The degree of platelet, leukocyte, and erythrocyte concentration or reduction for PRP, compared with results for the whole blood sample, was quantified for each dog and summarized for each concentrating system.

Results: The various PRP-concentrating systems differed substantially in the amount of blood processed, method of PRP preparation, amount of PRP produced, and platelet, leukocyte, and erythrocyte concentrations or reductions for PRP relative to results for whole blood.

Conclusions and clinical relevance: The characteristics of PRP products differed considerably. Investigators evaluating the efficacy of PRPs need to specify the characteristics of the product they are assessing. Clinicians should be aware of the data (or lack of data) supporting use of a particular PRP for a specific medical condition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomedical Technology / instrumentation*
  • Blood Platelets / physiology*
  • Dogs / blood*
  • Erythrocytes
  • Leukocytes
  • Plasmapheresis / instrumentation
  • Plasmapheresis / methods
  • Plasmapheresis / veterinary*
  • Platelet-Rich Plasma / chemistry*
  • Platelet-Rich Plasma / cytology*