Development of the Vertebrate Eye and Retina

Prog Mol Biol Transl Sci. 2015;134:397-414. doi: 10.1016/bs.pmbts.2015.06.006. Epub 2015 Jul 2.

Abstract

The mature, functional, and healthy eye is generated by the coordinated regulatory interaction of numerous and diverse developing tissues. The neural retina of the eye must undergo the neurogenesis of multiple retinal cell types in the correct ratios and spatial patterns. This chapter provides an overview of retinal development, and includes a summary of the process of eye organogenesis, a discussion of major principles of retinal neurogenesis, and describes some of the key molecular factors critical for retinal development. Defects in many of these factors underlie diseases of the eye, and an understanding of the process of retinal development will be critical for successful future applications of regenerative therapies for eye disease.

Keywords: Development; Eye; Morphogenesis; Neurogenesis; Photoreceptor; Regeneration; Retina; Retinal ganglion cell; Zebrafish.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Biological
  • Neurogenesis
  • Regeneration
  • Retina / embryology*
  • Retinal Neurons / pathology
  • Vertebrates / embryology*