YKL-40/CHI3L1 drives inflammation on the road of tumor progression

J Leukoc Biol. 2015 Dec;98(6):931-6. doi: 10.1189/jlb.3VMR0415-142R. Epub 2015 Aug 26.


Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/chitinase-3-like-1 protein-associated inflammation in promoting tumor progression.

Keywords: angiogenesis; cytokines; inflammatory bowel; pulmonary inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / immunology*
  • Animals
  • Chitinase-3-Like Protein 1
  • Humans
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation Mediators / immunology*
  • Lectins / immunology*
  • Neoplasm Metastasis
  • Neoplasm Proteins / immunology*
  • Neoplasms / immunology*
  • Neoplasms / pathology


  • Adipokines
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1
  • Inflammation Mediators
  • Lectins
  • Neoplasm Proteins