Prevention of Recurrent Staphylococcal Skin Infections

Infect Dis Clin North Am. 2015 Sep;29(3):429-64. doi: 10.1016/j.idc.2015.05.007.


Staphylococcus aureus infections pose a significant health burden. The emergence of community-associated methicillin-resistant S aureus has resulted in an epidemic of skin and soft tissue infections (SSTI), and many patients experience recurrent SSTI. As S aureus colonization is associated with subsequent infection, decolonization is recommended for patients with recurrent SSTI or in settings of ongoing transmission. S aureus infections often cluster within households, and asymptomatic carriers serve as reservoirs for transmission; therefore, a household approach to decolonization is more effective than measures performed by individuals alone. Novel strategies for the prevention of recurrent SSTI are needed.

Keywords: Decolonization; MRSA; Pediatrics; Prevention; Skin infection; Staphylococcal vaccine; Staphylococcus aureus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Carrier State / microbiology*
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / prevention & control
  • Community-Acquired Infections / therapy
  • Family Characteristics
  • Female
  • Humans
  • Methicillin Resistance
  • Methicillin-Resistant Staphylococcus aureus / growth & development
  • Recurrence
  • Risk Factors
  • Staphylococcal Skin Infections / epidemiology
  • Staphylococcal Skin Infections / microbiology
  • Staphylococcal Skin Infections / prevention & control*
  • Staphylococcal Skin Infections / transmission
  • Staphylococcus aureus / growth & development*


  • Anti-Bacterial Agents