Regulation of Body Composition and Bioenergetics by Estrogens

Endocrinol Metab Clin North Am. 2015 Sep;44(3):663-76. doi: 10.1016/j.ecl.2015.05.011. Epub 2015 Jun 20.


Evidence points to an important role of estradiol (E2) in the regulation of body composition and bioenergetics. Basic and preclinical research shows that the disruption of E2 signaling through either genetic manipulation or surgical intervention accelerates fat accumulation, with a disproportionate increase in abdominal fat. Clinical evidence for the regulation of body composition and bioenergetics by E2 is less consistent. Evidence exists both for and against menopause as the mediator of changes in body composition. Thus, a need remains to better understand the metabolic actions of estrogens in women and the potential impact on health after the menopause.

Keywords: Adiposity; Body composition; Energy expenditure; Energy intake; Estradiol; Estrogen receptor; Menopause; Ovariectomy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Body Composition / physiology*
  • Energy Metabolism / physiology*
  • Estrogens / metabolism*
  • Female
  • Humans
  • Menopause / physiology*


  • Estrogens