Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):128-33. doi: 10.4274/jcrpe.2011.


Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

MeSH terms

  • Adolescent
  • Calcifediol / blood
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Hashimoto Disease / blood
  • Hashimoto Disease / complications*
  • Hashimoto Disease / epidemiology
  • Humans
  • Male
  • Prevalence
  • Thyroid Function Tests
  • Vitamin B Deficiency / blood
  • Vitamin B Deficiency / complications*
  • Vitamin B Deficiency / epidemiology
  • Vitamin D / blood*
  • Vitamin D Deficiency / epidemiology


  • Vitamin D
  • Calcifediol