Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Cancer Manag Res. 2015 Aug 12;7:253-64. doi: 10.2147/CMAR.S58285. eCollection 2015.


Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.

Keywords: HIF-1; apoptosis; cancer; chemoresistance; signaling.

Publication types

  • Review