Architectural and Functional Commonalities between Enhancers and Promoters

Cell. 2015 Aug 27;162(5):948-59. doi: 10.1016/j.cell.2015.08.008.


With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Directed RNA Polymerases / metabolism
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation*
  • Humans
  • Promoter Regions, Genetic*
  • RNA, Long Noncoding / metabolism
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • RNA, Long Noncoding
  • Transcription Factors
  • DNA-Directed RNA Polymerases