Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes
- PMID: 26318059
- DOI: 10.1016/j.arr.2015.08.005
Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes
Abstract
Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.
Keywords: Drosophila melanogaster; Overexpression; Pro-longevity genes.
Copyright © 2015 Elsevier B.V. All rights reserved.
Similar articles
-
Aging and longevity genes.Acta Biochim Pol. 2000;47(2):269-79. Acta Biochim Pol. 2000. PMID: 11051192 Review.
-
A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster.Biochem Biophys Res Commun. 2010 Mar 26;394(1):112-8. doi: 10.1016/j.bbrc.2010.02.126. Epub 2010 Feb 23. Biochem Biophys Res Commun. 2010. PMID: 20184862
-
Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.Genet Mol Res. 2016 Oct 24;15(4). doi: 10.4238/gmr15048953. Genet Mol Res. 2016. PMID: 27813607
-
Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.Genes Dev. 2016 Jun 15;30(12):1409-22. doi: 10.1101/gad.282277.116. Epub 2016 Jun 16. Genes Dev. 2016. PMID: 27313316 Free PMC article.
-
Functional senescence in Drosophila melanogaster.Ageing Res Rev. 2005 Aug;4(3):372-97. doi: 10.1016/j.arr.2005.04.001. Ageing Res Rev. 2005. PMID: 16024299 Review.
Cited by
-
Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila.J Dev Biol. 2023 Oct 29;11(4):40. doi: 10.3390/jdb11040040. J Dev Biol. 2023. PMID: 37987370 Free PMC article.
-
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective.Biomolecules. 2023 May 30;13(6):912. doi: 10.3390/biom13060912. Biomolecules. 2023. PMID: 37371492 Free PMC article. Review.
-
An Alkaline Protease-Digestion of Silkworm Powder Enhances Its Effects Over Healthspan, Autophagy, and Mitochondria Function in a Rotenone-Induced Drosophila Model.Front Nutr. 2022 Jun 16;9:808295. doi: 10.3389/fnut.2022.808295. eCollection 2022. Front Nutr. 2022. PMID: 35782921 Free PMC article.
-
Social perception of young adults prolongs the lifespan of aged Drosophila.NPJ Aging Mech Dis. 2021 Sep 1;7(1):21. doi: 10.1038/s41514-021-00073-8. NPJ Aging Mech Dis. 2021. PMID: 34471134 Free PMC article.
-
Genome-Protecting Compounds as Potential Geroprotectors.Int J Mol Sci. 2020 Jun 24;21(12):4484. doi: 10.3390/ijms21124484. Int J Mol Sci. 2020. PMID: 32599754 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous
