The Triggering Receptor Expressed on Myeloid cells-1: A new player during acute myocardial infarction

Pharmacol Res. 2015 Oct;100:261-5. doi: 10.1016/j.phrs.2015.07.027. Epub 2015 Aug 28.


Following myocardial ischemia, an intense activation of the immune system occurs that leads to inflammatory cytokines and chemokines production and to the recruitment of neutrophils and mononuclear cells in the infarcted area. Although pro-inflammatory signals initiate the cellular events necessary for scar formation, excessive and prolonged inflammation promotes deleterious cardiac remodeling and dysfunction. The triggering receptor expressed on myeloid cells-1 (TREM-1) is a highly conserved immune-receptor expressed by neutrophils and monocytes that acts as an amplifier of the innate immune response. Blockade of TREM-1 activation protects from hyper-responsiveness and death during severe infections. Here we review the role of TREM-1 in orchestrating the inflammatory response that follows MI. TREM-1 deletion (Trem-1-/-) or modulation by the use of a short inhibitory peptide (LR12) dampens myocardial inflammation, limits leukocyte recruitment, and improves heart function and survival in mice or pigs. Moreover, the soluble form of TREM-1 (sTREM-1) is found in the plasma of patients suffering from an acute MI and its concentration is an independent predictor of death. This suggests that TREM-1 may constitute a new therapeutic target during acute MI.

Keywords: Inflammation; Myocardial infarction; TREM-1.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Humans
  • Inflammation / metabolism
  • Lauric Acids / metabolism
  • Leukocytes / metabolism
  • Membrane Glycoproteins / metabolism
  • Myeloid Cells / metabolism*
  • Myocardial Infarction / metabolism*
  • Oligopeptides
  • Receptors, Immunologic / metabolism
  • Rhodamines / metabolism
  • Triggering Receptor Expressed on Myeloid Cells-1


  • Lauric Acids
  • Membrane Glycoproteins
  • Oligopeptides
  • Receptors, Immunologic
  • Rhodamines
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1
  • nangibotide