Predicting the spatial organization of chromosomes using epigenetic data

Genome Biol. 2015 Aug 29;16(1):182. doi: 10.1186/s13059-015-0752-8.


Chromosome folding can reinforce the demarcation between euchromatin and heterochromatin. Two new studies show how epigenetic data, including DNA methylation, can accurately predict chromosome folding in three dimensions. Such computational approaches reinforce the idea of a linkage between epigenetically marked chromatin domains and their segregation into distinct compartments at the megabase scale or topological domains at a higher resolution. Please see related articles: and

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Chromatin / chemistry*
  • Chromatin / metabolism*
  • DNA Methylation*
  • Epigenesis, Genetic*
  • Histone Code*
  • Humans
  • Male


  • Chromatin