Serum bisphenol A and progression of type 2 diabetic nephropathy: a 6-year prospective study

Acta Diabetol. 2015 Dec;52(6):1135-41. doi: 10.1007/s00592-015-0801-5. Epub 2015 Sep 1.


Aims: Bisphenol A (BPA) is associated with diabetes and cardiovascular diseases. The aim of our study was to evaluate whether serum BPA could predict the progression of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D).

Methods: In this prospective study, a total of 121 patients with T2D and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2) were followed up for 6 years. The baseline values of serum BPA were measured. Renal function was measured as eGFR calculated by the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation. Development of CKD was defined as eGFR < 60 mL/min/1.73 m(2) at the last follow-up. Regression models were used to analyze the associations of serum BPA with the change in eGFR and the risk of CKD development.

Results: Baseline serum BPA concentration was 0.40 (0.17, 1.40) ng/mL. Duration of T2D, baseline waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, and serum BPA level were significantly negatively associated with the annual change and percentage change in eGFR. After adjusting for clinical factors, baseline serum BPA level had a significant negative association with the annual change in eGFR (β = -0.371, P < 0.001) and percentage change in eGFR (β = -0.391, P = <0.001). Multivariate logistic regression analysis showed that patients with high levels of serum BPA exhibited about a sevenfold increased risk of developing CKD compared to patients with low levels of serum BPA [odds ratio (OR) 6.65 (95 % CI 1.47, 30.04), P = 0.014].

Conclusion: Serum BPA may be a predictor of CKD in patients with T2D.

Keywords: Bisphenol A; Chronic kidney disease; Diabetes; Prospective study.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Benzhydryl Compounds / blood*
  • Blood Glucose / analysis
  • Blood Pressure
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Nephropathies / blood*
  • Diabetic Nephropathies / pathology*
  • Disease Progression
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Phenols / blood*
  • Prospective Studies
  • Renal Insufficiency, Chronic / epidemiology
  • Renal Insufficiency, Chronic / etiology
  • Risk
  • Waist Circumference


  • Benzhydryl Compounds
  • Blood Glucose
  • Hypoglycemic Agents
  • Phenols
  • bisphenol A