RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer

Thatchawan Thanasupawat; Aleksandra Glogowska; Maxwell Burg; G William Wong; Cuong Hoang-Vu; Sabine Hombach-Klonisch; Thomas Klonisch

doi:10.3389/fendo.2015.00127

RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer

Front Endocrinol (Lausanne). 2015 Aug 13:6:127. doi: 10.3389/fendo.2015.00127. eCollection 2015.

Authors

Thatchawan Thanasupawat¹, Aleksandra Glogowska¹, Maxwell Burg¹, G William Wong², Cuong Hoang-Vu³, Sabine Hombach-Klonisch⁴, Thomas Klonisch⁵

Affiliations

¹ Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
² Department of Physiology, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
³ Clinics of General, Visceral and Vascular Surgery, Martin Luther University , Halle/Salle , Germany.
⁴ Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.
⁵ Department of Human Anatomy and Cell Science, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Surgery, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada ; Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, College of Medicine, University of Manitoba , Winnipeg, MB , Canada.

Abstract

The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

Keywords: C1q/TNF-related proteins; CTRP8; RXFP1; brain tumor; cancer.

Publication types

Review

Grants and funding

R01 DK084171/DK/NIDDK NIH HHS/United States