Transgenerational Inheritance of Heart Disorders Caused by Paternal Bisphenol A Exposure

Environ Pollut. 2015 Nov;206:667-78. doi: 10.1016/j.envpol.2015.08.016. Epub 2015 Aug 31.

Abstract

Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices, resulting in an ubiquitous presence in the environment linked to human infertility, obesity or cardiovascular diseases. Both transcriptome and epigenome modifications lie behind these disorders that might be inherited transgenerationally when affecting germline. To assess potential effects of paternal exposure on offspring development, adult zebrafish males were exposed to BPA during spermatogenesis and mated with non-treated females. Results showed an increase in the rate of heart failures of progeny up to the F2, as well as downregulation of 5 genes involved in cardiac development in F1 embryos. Moreover, BPA causes a decrease in F0 and F1 sperm remnant mRNAs related to early development. Results reveal a paternal inheritance of changes in the insulin signaling pathway due to downregulation of insulin receptor β mRNAs, suggesting a link between BPA male exposure and disruption of cardiogenesis in forthcoming generations.

Keywords: Bisphenol A; Cardiac development; DNA methylation; Sperm mRNAs; Transgenerational inheritance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzhydryl Compounds / toxicity*
  • DNA Methylation / drug effects
  • Endocrine Disruptors / toxicity*
  • Female
  • Gene Expression Regulation, Developmental / drug effects
  • Heart Defects, Congenital / chemically induced*
  • Heart Defects, Congenital / embryology
  • Heart Defects, Congenital / genetics
  • Humans
  • Male
  • Organogenesis / drug effects
  • Organogenesis / genetics
  • Paternal Exposure / adverse effects*
  • Phenols / toxicity*
  • Receptor, Insulin / genetics
  • Receptor, Insulin / metabolism
  • Signal Transduction / drug effects
  • Spermatozoa / drug effects*
  • Zebrafish / genetics
  • Zebrafish / growth & development*

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • Receptor, Insulin
  • bisphenol A