Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins

Chem Commun (Camb). 2015 Oct 21;51(82):15137-40. doi: 10.1039/c5cc05933j. Epub 2015 Sep 1.


Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aptamers, Nucleotide / chemistry*
  • Biosensing Techniques*
  • Botulinum Toxins, Type A / analysis*
  • Botulinum Toxins, Type A / blood
  • Cattle
  • DNA / chemistry*
  • Electrochemistry
  • Nucleic Acid Conformation
  • Ricin / analysis*
  • Ricin / blood


  • Aptamers, Nucleotide
  • DNA
  • Ricin
  • Botulinum Toxins, Type A