Comparison of the effectivity of oral and intra-articular administration of tenoxicam in patients with knee osteoarthritis

Braz J Anesthesiol. Sep-Oct 2015;65(5):333-7. doi: 10.1016/j.bjane.2013.12.003. Epub 2014 Feb 6.


Background and objectives: Tenoxicam is widely used in osteoarthritis treatment and we aimed to compare the effectivity of oral and intra-articular administration of tenoxicam in osteoarthritis treatment.

Methods: This study was performed between 2011 and 2012 by retrospectively analyzing and comparing the findings of 60 patients who were clinically and radiologically diagnosed with knee degenerative osteoarthritis in Bünyan state hospital pain policlinic. 60 patients included in the study were divided into two groups. The first group (tenoxicam IA, n=30) included patient findings of those subjected to intra-articular injection of 20mg tenoxicam to the knee once a week for three weeks and the second group (oral tenoxicam, n=30) included patients who were administered 20mg oral tenoxicam once a day for three weeks. All patients were clinically evaluated pre-treatment and in the 1st week, 1st month and 3rd month post-treatment according to specified criteria.

Results and conclusions: Twenty two of 60 patients included in the study were male and 38 were female. In both groups significant improvements were detected in all of the observed parameters: visual analog scale, Western Ontario McMaster Osteoarthritis Index (pain, physical activity, knee stiffness) and Lequesne index scores and in the evaluations performed in 1st week, 1st month and 3rd month with respect to pre-treatment values. Besides, a better compliance to treatment and gastrointestinal system tolerability in tenoxicam IA group was also observed. Intra-articular tenoxicam administration could be thought as an alternative treatment method in patients with knee osteoarthritis who cannot use oral tenoxicam especially due to systemic gastrointestinal system side effects and those who have difficulties in adapting to treatment.

Keywords: Administração intra-articular; Intra-articular administration; Joelhos; Knee; Osteoarthritis; Osteoartrite; Tenoxicam.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Female
  • Humans
  • Injections, Intra-Articular
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / drug therapy*
  • Piroxicam / administration & dosage
  • Piroxicam / adverse effects
  • Piroxicam / analogs & derivatives*
  • Retrospective Studies


  • Anti-Inflammatory Agents, Non-Steroidal
  • Piroxicam
  • tenoxicam