Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats

Indian J Exp Biol. 1989 Jul;27(7):625-7.

Abstract

In myocardial necrosis produced by isoproterenol (beta-adrenergic agonist) marked increase in creatine phosphokinase, phospholipase and significant decrease in cardiac glycogen and phospholipid levels were observed. The enhanced levels of lipid peroxides, xanthine oxidase activity and lowering of superoxide dismutase may lead to excessive formation of free radicals resulting in cardiac cell damage. Nifedipine--a calcium antagonist, Propranolol--a beta-blocker and guggulsterone a lipid lowering agent showed marked reversal of these metabolic changes related to ischemia induced by isoproterenol.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular Agents / pharmacology*
  • Isoproterenol*
  • Lipid Peroxides / metabolism*
  • Male
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / pathology
  • Oxidoreductases / metabolism*
  • Pregnenediones / pharmacology
  • Rats
  • Superoxide Dismutase / metabolism
  • Xanthine Oxidase / metabolism

Substances

  • Cardiovascular Agents
  • Lipid Peroxides
  • Pregnenediones
  • pregna-4,17-diene-3,16-dione
  • Oxidoreductases
  • Superoxide Dismutase
  • Xanthine Oxidase
  • Isoproterenol