Current controversies and challenges in allergic rhinitis management

Expert Rev Clin Immunol. 2015;11(11):1205-17. doi: 10.1586/1744666X.2015.1081814. Epub 2015 Aug 29.


There are many obstacles in the path of effective allergy management, in general, and allergic rhinitis (AR) control, in particular. Chief among them are: insufficient symptom relief in some patients provided by some currently considered first-line AR treatments in real life; an over-reliance on randomized controlled trials to direct AR guideline recommendations; the need for a broader interpretation of the AR evidence base (to include randomized controlled trials and real-life studies); poorly designed and interpreted studies; and lack of an AR control concept and common language of control. These controversies are fully reviewed here and challenging solutions have been presented.

Keywords: allergic rhinitis; clinical relevance; control; guidelines; randomized controlled trials; real life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Practice Guidelines as Topic
  • Randomized Controlled Trials as Topic
  • Rhinitis, Allergic / immunology
  • Rhinitis, Allergic / therapy*