The effect of melatonin supplementation on the quality of sleep and weight status in postmenopausal women

Prz Menopauzalny. 2014 Dec;13(6):334-8. doi: 10.5114/pm.2014.47986. Epub 2014 Dec 30.


Aim of the study: We evaluated the effect of melatonin supplementation on the nutritional status of postmenopausal women.

Material and methods: The study included 56 women (51-65 years) and 25 healthy women (27-36 years). The emotional state was assessed using Hamilton Depression Rating Scale (HAM-D), the quality of sleep using Insomnia Severity Index (ISI). Body mass index (BMI) and waist-hip ratio (WHR) were also calculated. The patients were divided into 3 groups: group I (control) - 25 women with normal body weight, group II - 26 postmenopausal women with normal body weight, group III - 30 postmenopausal women with high body weight. In women from group II and III, routine laboratory tests, levels of thyroid-stimulating hormone (TSH), 17β-estradiol, prolactin, follicle-stimulating hormone (FSH) and the concentration of 6-hydroxymelatonin sulphate (6-HMS) in day/night urine fractions were determined. On the day of the examination, women remained on a liquid diet (1800 kcal). Next, a balanced diet of 1500 kcal and 5 mg of melatonin administration were recommended. The follow-up examinations were performed after 4, 8, 12, 16, 20 and 24 weeks.

Results: The patients from groups II and III showed similar mild levels of anxiety and depression and a significant degree of sleep disorders. In group III, lower urinary 6-HMS excretion was observed at night. In both groups a negative correlation was found between urinary 6-HMS excretion and the degree of sleep disorders. After 24 weeks, a statistically significant improvement of quality of sleep was obtained. A negative correlation was detected between urinary 6-HMS excretion and BMI.

Conclusion: Melatonin supplementation contributed to body weight reduction.

Keywords: body mass index; melatonin; menopause; sleep disorders.