Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic

Biomarkers. 2015;20(5):328-37. doi: 10.3109/1354750X.2015.1068867. Epub 2015 Jul 31.


Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer.

Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.

Materials and methods: Urinary biomarker concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.

Results: A five-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.

Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.

Keywords: Biomarkers; bladder cancer; invasiveness; recurrence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Biomarkers, Tumor / urine*
  • Humans
  • Models, Biological
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / urine


  • Biomarkers, Tumor