Serum testosterone does not affect bone mineral density in postmenopausal women

Arch Endocrinol Metab. 2015 Aug;59(4):292-6. doi: 10.1590/2359-3997000000085.


Objective: The purpose of the present study was to investigate the correlation between serum testosterone levels and bone mineral density (BMD) in postmenopausal women.

Materials and methods: The study group was made up of postmenopausal women admitted to our tertiary center. Serum calcium, phosphorus, albumin, parathyroid hormone (PTH), thyrotropin (TSH), 25-OH vitamin D, and total testosterone concentrations were measured. Subjects were categorized into three groups regarding bone mineral density (BMD) values: normal (n = 22), osteopenia (n = 21), and osteoporosis (n = 21). Subjects were also categorized into three groups according to serum testosterone levels: low testosterone (n = 10), normal testosterone (n = 42), and high testosterone (n = 12).

Results: No significant difference was found for serum testosterone, TSH, calcium, phosphorus, albumin, PTH, and 25-hydroxyvitamin D levels among patients with normal BMD, osteopenia, and osteoporosis (p > 0.05). Lumbar spine, total femur, femoral neck, trochanteric, intertrochanteric, and Ward's triangle BMD values were similar for the different testosterone levels (p > 0.05).

Conclusion: There was no correlation between serum testosterone levels and patient age, body-mass index, or any measured BMD values. Given the findings in our study, which failed to demonstrate a statistically significant relationship between testosterone and BMD, adjustment of other risk factors for osteoporosis might have a more distinctive effect in this setting.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Bone Density*
  • Bone Diseases, Metabolic / blood*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Middle Aged
  • Osteoporosis / blood*
  • Postmenopause / blood*
  • Testosterone / blood*


  • Testosterone