Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status

Arch Endocrinol Metab. 2015 Aug;59(4):364-6. doi: 10.1590/2359-3997000000091.


Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Papillary* / complications
  • Carcinoma, Papillary* / genetics
  • Carcinoma, Papillary* / surgery
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Thyroid Hormone Resistance Syndrome* / complications
  • Thyroid Hormone Resistance Syndrome* / genetics
  • Thyroid Hormone Resistance Syndrome* / surgery
  • Thyroid Neoplasms* / complications
  • Thyroid Neoplasms* / genetics
  • Thyroid Neoplasms* / surgery
  • Thyroidectomy

Supplementary concepts

  • Papillary Thyroid Microcarcinoma