Didecarboxylative Iron-Catalyzed Bidirectional Aldolization towards Diversity-Oriented Ketodiol Synthesis

Abstract

1,3-Acetonedicarboxylic acid was selectively activated by Fe(acac)3 , providing a synthetic platform for rapid synthesis of keto-3,3'-diols. The bidirectional aldol reaction was efficient for challenging aliphatic aldehydes, providing a rapid route to potentially bioactive complex structures.

Keywords: aldolization; decarboxylation; homogeneous catalysis; iron; polyols.