BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles

Fertil Steril. 2015 Nov;104(5):1162-7. doi: 10.1016/j.fertnstert.2015.07.1162. Epub 2015 Aug 31.


Objective: To evaluate the association between carriage of BRCA1/2 mutations and ovarian performance, as demonstrated by in vitro fertilization (IVF) outcomes.

Design: Retrospective cohort study.

Setting: Two tertiary IVF centers.

Patient(s): BRCA mutation carriers undergoing IVF for preimplantation genetic diagnosis (PGD) or fertility preservation were compared with non-BRCA PGD or fertility preservation patients, matched by age, IVF protocol, IVF center, and cancer disease status.

Intervention(s): In vitro fertilization cycles for PGD and fertility preservation.

Main outcome measure(s): Outcome of IVF: oocyte yield, poor response rate, number of zygotes, pregnancy rates.

Result(s): A total of 62 BRCA mutation carriers and 62 matched noncarriers were included; 42 were fertility preservation breast cancer patients, and 82 were PGD non-cancer patients. Mean (± SD) age of patients was 32 ± 3.58 years. Number of stimulation days and total stimulation dose were comparable between carriers and noncarriers. Their cycles resulted in comparable oocyte yield (13.75 vs. 14.75) and low response rates (8.06% vs. 6.45%). Number of zygotes, fertilization rates, and conception rates were also comparable.

Conclusion(s): Both healthy and cancer-affected BRCA mutation carriers demonstrated normal ovarian response in IVF cycles.

Keywords: BRCA1; BRCA2; IVF; fertility preservation; ovarian reserve.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • BRCA1 Protein / genetics*
  • BRCA2 Protein / genetics*
  • DNA Mutational Analysis
  • Embryo Transfer
  • Female
  • Fertility Preservation
  • Fertilization in Vitro*
  • Genetic Carrier Screening
  • Genetic Predisposition to Disease
  • Heterozygote*
  • Humans
  • Infertility, Female / diagnosis
  • Infertility, Female / genetics
  • Infertility, Female / physiopathology
  • Infertility, Female / therapy*
  • Israel
  • Mutation*
  • Oocyte Retrieval
  • Ovary / physiopathology*
  • Phenotype
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Rate
  • Preimplantation Diagnosis
  • Retrospective Studies
  • Risk Factors
  • Tertiary Care Centers
  • Treatment Outcome


  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human